Syros Pharma tanks as it updates on SELECT-AML-1 study

14 August 2024

US oncology focused biotech Syros Pharmaceuticals (Nasdaq: SYRS) announced that it will discontinue enrollment in the SELECT-AML-1 Phase II clinical trial, with the news sending the firm’s shares plummeting 62% to $1.92 yesterday.

The study was evaluating the triplet regimen of tamibarotene in combination with venetoclax and azacitidine compared to the doublet regimen of venetoclax and azacitidine in newly diagnosed, unfit patients with acute myeloid leukemia (AML) and RARA gene overexpression. This decision is based on the results of a prespecified interim analysis of the trial.

Data from 51 patients enrolled in SELECT-AML-1 were reviewed on August 9, 2024. This review included a prespecified non-binding futility analysis conducted on the first 40 randomized patients after the fortieth randomized patient received approximately three months of study drug or discontinued treatment.

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