Shareholders do not share Bicycle cheer

16 December 2024

Bicycle Therapeutics (Nasdaq: BCYC), a UK-headquartered pharma company developing a new class of therapeutics based on its proprietary bicyclic peptide technology, closed a third lower on Friday.

The company earlier announced data updates across its zelenectide pevedotin program and development strategy leveraging NECTIN4 gene amplification.

There was topline combination data for zelenectide pevedotin plus pembrolizumab - an immuno-oncology blockbuster sold by Merck & Co (NYSE: MRK) as Keytruda - in first-line metastatic urothelial cancer (mUC), which demonstrated a 60% overall response rate, in line with existing therapies.

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