Semaglutide shows superior improvement in both liver fibrosis and MASH resolution

1 November 2024

Denmark’s Novo Nordisk (NOV: N) bucked a down trending market today, rising 1% on promising research results.

The diabetes and obesity power house announced the headline results from part 1 of the ongoing ESSENCE trial, a pivotal phase 3, 240-week, double-blinded trial in 1,200 adults with metabolic dysfunction-associated steatohepatitis (MASH) and moderate to advanced liver fibrosis (stage 2 or 3).

Part 1 of the ESSENCE trial evaluated the effect of once-weekly semaglutide 2.4mg on liver tissue (histology) compared to placebo on top of standard of care for the first 800 randomised people at 72 weeks.

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