Roche’s Itovebi-based regimen ‘has potential to become new standard of care’

28 January 2025

Shares in Swiss pharma giant Roche (ROG: SIX0 were more than 1% higher on Tuesday afternoon, following the announcement of positive top-line results from the overall survival (OS) analysis of the Phase III INAVO120 study.

The trial is investigating Itovebi (inavolisib) in combination with palbociclib (Ibrance) and fulvestrant for people with PIK3CA-mutated, hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, endocrine-resistant, locally advanced or metastatic breast cancer.

Levi Garraway, Roche’s chief medical officer and head of global product development, said: “The INAVO120 OS results show that the Itovebi-based regimen not only delayed disease progression, but also helped people with advanced HR-positive, PIK3CA-mutated breast cancer live longer. 

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