Regeneron’s DB-OTO demonstrates dramatic hearing improvement

25 February 2025

US biotech Regeneron Pharmaceuticals (Nasdaq: REGN) says that its investigational gene therapy DB-OTO showed clinically-meaningful hearing improvements in nearly all children with profound genetic hearing loss due to variants of the otoferlin (OTOF) gene.

The latest results from the potentially pivotal Phase I/II CHORD trial were shared in an oral presentation at the Association for Research in Otolaryngology’s (ARO) 48th Annual MidWinter Meeting.

12 participants have received DB-OTO to date – of whom nine were administered an intracochlear injection in one ear, and three received it bilaterally

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