Prospects for datopotamab deruxtecan dented by update
Japan’s Daiichi Sankyo (TYO: 4502) and Anglo-Swedish pharma major AstraZeneca (LSE: AZN) were trading lower on Tuesday after announcing topline results from the TROPION-Breast01 study.
The Phase III trial of datopotamab deruxtecan compared to investigator’s choice of chemotherapy - which previously met the dual primary endpoint of progression-free survival (PFS) - did not achieve statistical significance in the final overall survival (OS) analysis in patients with inoperable or metastatic hormone receptor (HR) positive, HER2 low or negative breast cancer previously treated with endocrine-based therapy and at least one systemic therapy.
These data will be shared with regulatory authorities currently reviewing applications for this indication.
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