Positive top-line results for Incyte’s Monjuvi in FL

16 August 2024

US biotech Incyte (Nasdaq: INCY) has announced positive top-line results from the pivotal Phase III inMIND trial evaluating the efficacy and safety of Monjuvi (tafasitamab).

The drug isa humanized Fc-modified cytolytic CD19 targeting monoclonal antibody, or placebo in combination with lenalidomide and rituximab compared to lenalidomide and rituximab alone in patients with relapsed or refractory follicular lymphoma (FL).

Incyte noted that the trial met its primary endpoint of progression free survival (PFS) by investigator assessment in FL. It also met key secondary endpoints of PFS in the overall population by investigator assessment as well as the positron-emission tomography-complete response rate in the FDG-avid FL population. In addition, the secondary endpoint of PFS results by blinded independent review are consistent with investigator based PFS results. No new safety signals with tafasitamab were observed.

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