Phase II win for Boston Pharma’s efimosfermin alfa in MASH
US clinical-stage biopharmaceutical company Boston Pharmaceuticals has announced positive results from a Phase II study evaluating the safety and efficacy of once-monthly efimosfermin alfa (formerly known as BOS-580), a long-acting FGF21 analogue, in participants with stage F2/F3 fibrosis due to metabolic dysfunction-associated steatohepatitis (MASH).
The B-Flexion portfolio company said treatment with efimosfermin led to significant improvements in fibrosis ≥1 stage without worsening of MASH, and MASH resolution without worsening of fibrosis over 24 weeks. In the study, efimosfermin demonstrated a favorable tolerability profile.
These top-line results will be presented on November 19 in a late-breaking oral presentation at the American Association for the Study of Liver Diseases (AASLD) taking place in San Diego.
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