PharmaMar releases top-line data on Zepzelca and Tecentriq combo in lung cancer
Shares of Spanish drugmaker PharmaMar (MSE: PHM) leapt more than 28% to 63.70 euros today, after it announced positive clinical trial findings for its combo lung cancer treatment, under development with USA-based Jazz Pharmaceuticals (Nasdaq: JAZZ), which rose 4.2%.
The companies released positive top-line results from the Phase III clinical trial evaluating Zepzelca (lurbinectedin) in combination with the PD-L1 inhibitor Roche’s (ROG: SIX) atezolizumab (Tecentriq) compared to atezolizumab alone when administered as a maintenance treatment for adults with extensive-stage small cell lung cancer (ES-SCLC) following induction therapy with carboplatin, etoposide and atezolizumab.
The combination of lurbinectedin and atezolizumab demonstrated a statistically-significant improvement in the primary endpoints of overall survival (OS) and progression-free survival (PFS), as assessed by an independent review facility (IRF), compared to treatment with atezolizumab alone.
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