Zafgen announces positive data for beloranib, despite earlier problems
Shares in US biotech firm Zafgen (Nasdaq: ZFGN) more than doubled initially on Wednesday, after the company reported positive data on its obesity drug beloranib.
The randomized ZAF-311 study, a pivotal, double-blind, placebo-controlled Phase III trial evaluating the safety and efficacy of beloranib, a MetAP2 inhibitor, in patients with Prader-Willi syndrome (PWS) during a six-month treatment period, met its primary endpoints, said the company.
It is hoped the announcement will help persuade the US Food and Drug Administration to allow Zafgen to restart trials on the drug after they were put on "clinical hold" following two patient deaths.
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