Verona value bulldozed by Phase II failure
UK-based Verona Pharma (Nasdaq: VRNA) closed more than 30% down on Monday based on disappointing trial data in chronic obstructive pulmonary disease (COPD).
The company announced top-line data from its three-day Phase II clinical pharmacology trial evaluating the effect of two different doses of nebulized ensifentrine (RPL554) when used with Boehringer Ingelheim’s LAMA/LABA combination Stiolto Respimat (tiotropium/olodaterol).
Ensifentrine failed to meet its primary endpoint in the study, showing no significant improvement on placebo of peak forced expiratory volume in one second after the morning dose on day three of treatment.
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