Valeant and Progenics file NDA for oral Relistor

23 June 2015

Canada’s Valeant Pharmaceuticals International (VRX: TO) has submitted a New Drug Application to the US Food and Drug Administration for Relistor (methylnaltrexone bromide) tablets for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.

USA-based Progenics Pharmaceuticals (Nasdaq: PGNX) licensed Relistor exclusively to Valeant for commercialization and development.

Relistor is a peripherally acting mu-opioid receptor antagonist specifically designed to block the constipating effects of opioid pain medications in the gastrointestinal tract. Relistor does not cross the blood-brain barrier, therefore relieving the distressing effects of the constipation without affecting the analgesic effect of the opioid.

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