Trial stoppages hit macrocycles specialist Polyphor

13 May 2019

Shares in Swiss firm Polyphor (SIX: POLN) have been badly affected by a decision to pause enrollment for the Phase III PRISM-MDR and PRISM-UDR trials after “higher than expected” acute kidney injuries in the former study.

Trading at around 10.40 Swiss francs on Monday morning, the firm’s stock has lost more than half its value since the announcement on Thursday.

The trials are evaluating the firm’s experimental therapy murepavadin, a highly specific antibiotic with a novel mode of action, in people with nosocomial pneumonia.

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