Travere undeterred by trial miss for rare kidney disease drug

3 May 2023

A third of the value of Travere Therapeutics (Nasdaq: TVTX) stock has been wiped out following the failure of the Phase III DUPLEX study of sparsentan.

The San Diegan rare disease specialist is trialing the novel dual endothelin angiotensin receptor (DEAR) blocker in focal segmental glomerulosclerosis (FSGS), a devastating kidney disease.

A progressive and complex disorder, FSGS is regarded by scientists as one of the more difficult diseases in this class to study.

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