Takeda unit posts updated survival data with HL drug candidate Adcetris

15 June 2012

USA-based Millennium, a wholly owned oncology subsidiary of Takeda Pharmaceutical (TYO: 4502), yesterday announced updated survival data from a pivotal Phase II clinical trial of single-agent Adcetris (brentuximab vedotin) in patients with relapsed or refractory Hodgkin lymphoma (HL) after autologous stem cell transplant (ASCT) showing that the median overall survival has not been reached after a 26.5 month median follow-up.

The data will be reported during an oral presentation at the 17th European Hematology Association (EHA) Annual Meeting being held June 14-17, 2012 in Amsterdam, Netherlands. Brentuximab vedotin is an antibody-drug conjugate (ADC) directed to CD30, a defining marker of the majority of types of HL.

Takeda gained rights to market Adcetris in territories excluding the USA and Canada from USA-based Seattle Genetics under the terms of a collaboration agreement, which involved an upfront to the US firm of $60 million and potentially more than $230 million in milestones (The Pharma Letter December 15, 2009). Seattle Genetics has US and Canadian commercialization rights.

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