Swiss rivals present divergent results in advanced skin cancer

12 September 2017

Roche stock (ROG: SIX) dropped almost 1.5% yesterday after the cancer giant revealed the Phase III BRIM8 study had missed its primary endpoint of disease-free survival (DFS) in patients with advanced melanoma.

BRIM8 is designed to investigate the efficacy and safety of post-surgical Zelboraf (vemurafenib) as a treatment for people with completely resected, BRAF V600 mutation-positive melanoma.

Results from the trial, which were presented at the European Society of Medical Oncology (ESMO) congress in Madrid, show that median DFS with Zelboraf was 23.1 months, versus 15.4 months with placebo.

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