Strong new Ph III data for PT010 severe COPD
Full results from the positive Phase III ETHOS trial showed AstraZeneca’s (LSE: AZN) triple-combination therapy PT010 (budesonide/glycopyrronium/formoterol fumarate) demonstrated a statistically-significant reduction in the rate of moderate or severe exacerbations compared with two dual-combination therapies in patients with moderate to very severe chronic obstructive pulmonary disease (COPD).
Compared with glycopyrronium/formoterol fumarate, PT010 achieved a 24% reduction (p<0.001) in exacerbations. PT010 achieved a 13% reduction (p=0.003) compared with PT009 (budesonide/formoterol fumarate). The dual-combination therapies used as comparators in the trial represent recommended therapeutic classes for the treatment of COPD.
In a key secondary endpoint, PT010 showed a 46% reduction in the risk of all-cause mortality compared with glycopyrronium/formoterol fumarate (unadjusted p=0.01), said AstraZeneca, whose shares edged up 1.25% to £84,47 by mid-morning today.
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