Strong data on AstraZeneca's vandetanib in advanced papillary or follicular thyroid cancer; FDA clears new Faslodex dosage
Anglo-Swedish drug major AstraZeneca yesterday presented positive results at the International Thyroid Congress in Paris, France, from a Phase II study evaluating the investigational drug vandetanib for the treatment of patients with locally advanced or metastatic papillary or follicular thyroid cancer.
This study, ZACTHYF, showed that treatment with vandetanib significantly improved progression-free survival (PFS), the primary endpoint of the study, compared to placebo (Hazard Ratio=0.63, p=0.008). Median PFS was improved by 5 months (11.0 months for vandetanib and 5.8 months for placebo patients).
Regulatory filing later this year
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