Shionogi reports success in late stage trial for drug to treat constipation from painkiller medication
Japanese pharmaceutical company Shionogi (TYO: 4507) on Wednesday said a late-stage trial of its drug candidate to treat constipation caused by painkiller medication has met its primary and secondary endpoint.
The company in a statement said this is the third Phase III trial for its once-daily naldemedine to treat opioid-induced constipation (OIC). Naldemedine is an investigational, oral, peripherally acting mu-opioid receptor antagonist (pamora).
Juan Camilo Arjona Ferreira, senior vice president clinical development, said: "OIC is different from other forms of constipation as it is the most common side effect of chronic opioid therapy. OIC can hamper everyday activities, reduce work productivity and negatively affect a person's well-being."
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