Sage’s dalzanemdor latest victim of Parkinson’s

17 April 2024

US brain health company Sage Therapeutics (Nasdaq: SAGE) was trading more than 19% lower at lunchtime Wednesday.

The company earlier announced top-line results from PRECEDENT, a double-blind, placebo-controlled Phase II study of the investigational oral medicine dalzanemdor (SAGE-718) in people with mild cognitive impairment in Parkinson’s disease.

PRECEDENT did not meet its primary endpoint of demonstrating statistically-significant difference from baseline in participants treated on a measure of cognitive ability in adults at day 42.

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