Research pivot for eFFECTOR after mid-stage disappointment

5 April 2024

A trial flop for eFFECTOR Therapeutics (Nasdaq: EFTR) has prompted the Californian firm to drop development of its lead candidate, tomivosertib, in lung cancer.

The company, which focuses on selective translation regulator inhibitors, plans to carry on with a trial testing the candidate in acute myeloid leukemia (AML).

Announcing top-line results from the Phase II KICKSTART trial, the firm said median progression-free survival (PFS) was 13 weeks, compared with 11.7 weeks for the placebo arm.

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