Positive new OS data for Xtandi in prostate cancer

11 February 2020

Japan’s Astellas Pharma (TYO: 4503) and US giant Pfizer (NYSE: PFE) have announced today results of the final overall survival (OS) analysis from the Phase III PROSPER trial, which evaluated Xtandi (enzalutamide) plus androgen deprivation therapy (ADT) versus placebo plus ADT in men with non-metastatic castration-resistant prostate cancer (nmCRPC).

The results demonstrated a statistically-significant improvement in OS in patients with nmCRPC who were treated with Xtandi plus ADT. OS was a key secondary endpoint of the trial. In a preliminary analysis, adverse events were generally consistent with those previously reported from PROSPER. Detailed efficacy and safety results from the final PROSPER OS analysis will be shared at a later date.

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