Portola's andexanet alfa trial meets endpoints in second half of Phase III
Portola Pharmaceuticals (Nasdaq: PTLA) has announced that its andexanet alfa met the primary and secondary endpoints of the second part of Phase III ANNEXA-A trial.
The product is an experimental antidote to Eliquis (apixaban) from Pfizer (NYSE: PFE) and Bristol-Myers Squibb (NYSE: BMY), and in the study it rapidly reversed the anticoagulating effects of Eliquis, as indicated by anti-Factor Xa activity, and maintained these effects throughout the duration of the infusion.
The study comprised 31 healthy volunteers aged 50 to 75 who were treated with Eliquis twice a day for four days, then randomized to receive andexanet alfa, administered as a bolus followed by continued infusion for 120 minutes, or placebo.
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