Pixuvri flunks confirmatory trial in non-Hodgkin B-cell lymphoma

10 July 2018

Six years after US biotech CTI BioPharma (Nasdaq: CTIC) was granted conditional approval in the European Union for its non-Hodgkin B-cell lymphoma (NHL) product Pixuvri (pixantrone), the drug has failed a key Phase III confirmatory trial.

The news has plunged the product’s future into doubt and knocked a fifth off the share price of the firm, which was formerly known as Cell Therapeutics.

In the trial, Pixuvri (pixantrone) plus MabThera (rituximab) failed to improve on progression-free survival (PFS) for MabThera plus chemo.

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