Phase III trial for Truqap misses primary endpoint

18 June 2024

The CAPItello-290 Phase III trial for Truqap (capivasertib) missed its goal, UK pharma major AstraZeneca (LSE): AZN) revealed this morning.

The company noted that Truqap in combination with paclitaxel in patients with locally advanced (inoperable) or metastatic triple-negative breast cancer (TNBC) did not meet the dual primary endpoints of improvement in overall survival (OS) versus paclitaxel in combination with placebo in either the overall trial population or in a subgroup of patients with tumors harboring specific biomarker alterations (PIK3CA, AKT1 or PTEN).

The follows a similar outcome for Swiss pharma giant Roche’s (ROG: SIX) AKT inhibitor ipatasertib in the same setting, which earlier this year missed the main goal of the IPATunity170 trial.

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