Phase III success for Novartis' MS drug BAF312

25 August 2016

Swiss pharma giant Novartis (NOVN: VX) has announced positive Phase III results showing the efficacy of its BAF312 (siponimod) candidate in secondary progressive multiple sclerosis (SPMS).

The drug met its primary endpoint of reducing the risk of three-month confirmed disability progression versus placebo in the Phase III EXPAND trial, the largest randomized, controlled study in SPMS to date.

There are currently very limited treatment options for SPMS, a form of multiple sclerosis associated with gradual worsening of symptoms and accumulation of disability, independent of relapses.

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