Phase IIIb data backs Daiichi Sankyo's Lixiana in atrial fibrillation patients undergoing cardioversion

30 August 2016

Japanese drug major Daiichi Sankyo (TYO: 4568) has announced results from the global Phase IIIb ENSURE-AF study of Lixiana (edoxaban) in patients with non-valvular atrial fibrillation (NVAF) undergoing cardioversion.

Data demonstrated that the oral, once-daily drug, which is known as Savaysa in the USA, met the study’s primary endpoints, showing comparable efficacy and safety to well-managed enoxaparin/warfarin for the prevention of stroke and other blood clot complications.

The results from ENSURE-AF were presented on Tuesday at the European Society of Cardiology (ESC) Congress 2016 in Rome, and published in The Lancet. They show that Lixiana may be an effective and well-tolerated alternative to conventional treatment with enoxaparin and a vitamin K antagonist (VKA), and may allow prompt cardioversion to be performed with transoesophageal echocardiography (TEE)

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