Pfizer's Sutent meets primary endpoint in renal cell carcinoma trial
US pharma giant Pfizer's (NYSE: PFE) Sutent (sunitinib malate) has met its primary endpoint in a Phase III trial of improving disease-free survival (DFS) in patients with renal cell carcinoma (RCC).
Its S-TRAC (Sunitinib Trial in Adjuvant RenalCancer) trial tested Sutent versus placebo in the adjuvant setting and identified improved DFS as determined by blinded independent central review in RCC patients who are at high risk for recurrence after surgery.
The S-TRAC trial is the first RCC trial of a tyrosine kinase inhibitor (TKI) to prolong DFS in the adjuvant setting. The concept of adjuvant therapy is to help lower the risk of cancer recurrence in patients with early-stage cancer.
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