Pfizer inks deal with Clear Creek Bio targeting SARS-CoV-2 papain-like protease
Armed with a huge money pile generated from its COVID-19 anti-viral Paxlovid (nirmatrelvir and ritonavir tablets), not to mention the mammoth success of the Comirnaty vaccine, Pfizer (NYSE: PFE) is looking to further expand its offering in the sector.
The US pharma giant has announced a research collaboration and exclusive license agreement with privately held Clear Creek Bio to advance the discovery and development of potential inhibitors of the SARS-CoV-2 papain-like protease (PLpro) for the oral treatment of COVID-19. PLpro is an essential enzyme, which, along with the main protease (Mpro), plays an important role in viral replication.
This program will expand Pfizer’s innovative anti-infective pipeline and, if successful, will complement Pfizer’s existing portfolio of COVID-19 products with direct-acting antiviral agents against different SARS-CoV-2 targets.
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