New Cleveland Clinic-led research shows that the COVID-19 antivirals Paxlovid (nirmatrelvir) and Lagevrio (molnupiravir)—from Pfizer (NYSE: PFE) and Merck & Co (NYSE: MRK), respectively - reduce risk of hospitalization and death in high-risk patients with mild disease, even with Omicron subvariants.
The observational study, published in JAMA Network Open, analyzed nearly 70,000 patients diagnosed with COVID-19 at Cleveland Clinic between April 2022 to February 2023, finding that nirmatrelvir lowered risk of death by 84% and molnupiravir by 77% compared to no treatment.
"The findings regarding the effectiveness of Lagevrio are especially crucial due to notable Paxlovid drug-drug interactions"Both drugs also reduced combined risk of hospitalization and death by more than 40%. Importantly, the treatments were effective across all patient subgroups and against newer strains like BQ.1.1 and XBB.1.5.
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
7 day trial access
Become a subscriber
Or £77 per month
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
Copyright © The Pharma Letter 2024 | Headless Content Management with Blaze