OncoGenex' custirsen fails in late-stage prostate cancer trial

16 August 2016

Canada-based OncoGenex Pharmaceuticals (Nasdaq: OXGI) has released disappointing result from the final analysis of AFFINITY, the Phase III trial of custirsen in men with metastatic castrate-resistant prostate cancer (CRPC) whose disease has progressed after treatment with docetaxel.

The trial did not meet the primary endpoint of demonstrating a statistically-significant improvement in overall survival for patients treated with custirsen in combination with cabazitaxel/prednisone compared to cabazitaxel/prednisone alone.

OncoGenex’ shares plunged 35% to $0.58 in pre-market trading, and by mid-morning they were down 43.6% at $0.50.

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