Novel breast cancer drug highlighted at ESMO 2018 - but safety worries nag
At a late-breaking session of Saturday’s Presidential Symposium at ESMO, Novartis (NOVN: VX) revealed striking breast cancer data from the Phase III SOLAR-1 trial of its PI3K blocker alpelisib.
The trial, which compared alpelisib plus the hormone blocker fulvestrant with fulvestrant alone, found a median progression-free survival (PFS) of 11 months for the test group, compared with 5.7 months.
Overall response rate (ORR), indicating a reduction in tumor size of at least 30%, was 36% compared with 16%.
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