NICE backs Forxiga for chronic heart failure

18 May 2023

Today’s announcement that the UK’s National Institute for Health and Care Excellence (NICE) has published Final Draft Guidance (FDG) recommending dapagliflozin for adult patients with symptomatic chronic heart failure (HF) with preserved or mildly reduced ejection fraction (LVEF of more than 40%) in England and Wales is a significant day for patients and the wider cardiology community.

Dapagliflozin, marketed by UK pharma major AstraZeneca (LSE: AZN) under the trade names Forxiga and Farxiga, is the first and only NICE recommended treatment for this type of heart failure, potentially impacting up to half a million patients in England and Wales.

The drug generated global sales of $4.4 billion for AstraZeneca last year. It is expected to see an increase in uptake with the approval of additional indications, granting AstraZeneca a majority share of the total HF market, according to GlobalData analysts.

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