New real world evidence validates pivotal clinical trial outcomes for Brilinta in MI patients
Real world evidence recently published in the European Heart Journal demonstrates that AstraZeneca’s (LSE: AZN) Brilinta (ticagrelor) is associated with a lower risk of all-cause death, re-admission with myocardial infarction (MI) or stroke (composite endpoint), compared to clopidogrel, in the treatment of people with MI.
The PRACTICAL study prospectively measured outcomes from the Swedish registry of 45,073 patients with MI, SWEDEHEART. The study recorded outcomes from 11,954 acute coronary syndrome (ACS) patients discharged on ticagrelor and 33,119 on clopidogrel from 2010 to 2013. The results showed:
- Compared with clopidogrel, ticagrelor was associated at two years with a lower risk of all-cause death, readmission with MI or stroke, as well as death alone; and
- Consistent results at 12 months, with the primary efficacy endpoint occurring in 5.6 patients per 100 patient-years with ticagrelor versus 16.8 patients per 100 patient-years with clopidogrel.
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