New body of evidence differentiating Inpefa as a dual oral inhibitor of SGLT2 and SGLT1

15 May 2024

Texas, USA-based drugmaker Lexicon Pharmaceuticals (Nasdaq: LXRX) saw its shares edge up 2.7% to by close of trading yesterday and a further 2% to $1.96 pre-market as its announced new research results on its heart failure drug.

Lexicon released new post-hoc analysis of clinical data showing that Inpefa (sotagliflozin), a dual oral inhibitor of SGLT2 and SGLT1, reduced the risk of heart failure-related events across a diverse population of patients, including patients with preserved ejection fraction (HFpEF).

Researchers noted that Inpefa Iappeared to be particularly effective in reducing the risk of heart failure events in patients with an obesity-related HFpEF phenotype. These findings, based on a pooled, patient-level analysis of data from the SOLOST-WHF and SCORED pivotal clinical trials, were presented today at the Annual Congress of the Heart Failure Association of the European Society of Cardiology (ESC) in Lisbon, Portugal.

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