Negative NICE final draft guidance issued on Cotellic with Zelboraf
The National Institute for Health and Care Excellence (NICE), the medicines cost-effectiveness watchdog for England, has today issued final draft guidance, repeating its negative view on Swiss pharma giant Roche’s (ROG: SIX) Cotellic (cobimetinib) with vemurafenib (Zelboraf, also from Roche) for a type of advanced skin cancer.
NICE does not recommend cobimetinib with vemurafenib for people with advanced BRAF V600 mutation-positive melanoma that has spread and can’t be surgically removed.
The committee agreed the combination offers life extending benefit compared to vemurafenib alone, however compared to alternative treatments it is too expensive. About 1,000 people would have been eligible each year.
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