Nacuity inks licensing deal with Arctic for HCCAA therapy NPI-001 in Iceland

14 September 2022

Privately-held US developer of healthcare therapies Nacuity Pharmaceuticals and Icelandic firm Arctic Therapeutics International have entered into an exclusive licensing agreement and strategic partnership for the development and commercialization of NPI-001 in Iceland for the treatment of hereditary cystatin C amyloid angiopathy (HCCAA).

HCCAA is an inherited, rare amyloid disease primarily seen in the Icelandic population that leads to paralysis, dementia and death in young adults.

NPI-001 is Nacuity’s proprietary, GMP-grade formulation of N-acetylcysteine amide (NACA) being developed for the treatment of a broad range of diseases associated with oxidative stress, including HCCAA, which is caused by a leucine to glutamine variant of human cystatin C (hCC). Clinical and in vitro data utilizing N-acetylcysteine and NACA for the treatment of HCCAA support a strong mechanistic rationale for NPI-001 as a potential effective therapy for the treatment of HCCAA.

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