Madrigal Pharma's resmetirom continues to score well in NASH study

13 November 2023

US clinical-stage liver disease specialist Madrigal Pharmaceuticals’ (Nasdaq: MDGL) shares – already up about 100% this year – gained a further 1.8% to $138.84 on Friday, as it announced new data from the Phase III MAESTRO-NASH trial demonstrating broad treatment effects of resmetirom on non-invasive tests that may be used to monitor non-alcoholic steatohepatitis (NASH) with liver fibrosis.

The non-invasive testing data and multiple additional abstracts from the MAESTRO program were presented at the American Association for the Study of Liver Diseases (AASLD) Liver Meeting.

Resmetirom is a liver-directed thyroid hormone receptor (THR)-β agonist oral therapy that is designed to target key underlying causes of NASH. Madrigal claims that it is the only investigational therapy for NASH that has achieved both fibrosis improvement and NASH resolution primary endpoints in a Phase III trial.

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