Lynparza fails Phase III endpoint in gastric cancer trial

18 May 2016

Anglo-Swedish company AstraZeneca (LSE: AZN) has announced that its cancer drug Lynparza (olaparib) in combination with paclitaxel chemotherapy has failed to increase overall survival (OS) in patients with advanced gastric cancer.

The news will come as a blow to the company which has been increasing its focus on cancer treatments in a bid to replace lost revenues from its bestselling cholesterol pill Crestor (rosuvastatin).

Sean Bohen, executive vice president, global medicines development and chief medical officer, at AstraZeneca, said: “While there was a numerical trend for survival benefit with Lynparza plus paclitaxel in the GOLD trial, we are disappointed that this did not reach statistical significance.”

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