Loss of form for Lynparza as scientists call off colon cancer trial

20 July 2022

In a rare disappointment for leading PARP inhibitor Lynparza (olaparib), researchers are to stop the Phase III LYNK-003 trial after independent monitors judged it likely to fail.

Developers AstraZeneca (LSE: AZN) and Merck & Co (NYSE: MRK) have been testing the drug, with and without Avastin (bevacizumab), for people with unresectable or metastatic colorectal cancer who have not progressed following first-line treatment.

No new safety signals were observed with Lynparza in the trial, one of several initiated by Merck as part of its collaboration with the British firm.

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