Ligand inks expanded licensing deal with Marinus

6 April 2017

US drugmaker Ligand Pharmaceuticals (Nasdaq: LGND) has entered into commercial license and supply agreements with Marinus Pharmaceuticals (Nasdaq: MRNS), granting rights to use Ligand’s Captisol in the formulation of its intravenous (IV) ganaxolone.

Captisol is a patent protected, chemically-modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs. Marinus is preparing to initiate clinical trials with Captisol-enabled ganaxolone IV in patients with postpartum depression (PPD) and status epilepticus (SE).

This accord replaces the prior research agreement signed in 2014 which allowed Marinus to evaluate ganaxolone IV with Captisol in preclinical and Phase I clinical studies. Under this new deal, Marinus receives exclusive worldwide rights to Captisol-enabled ganaxolone for use in humans. In addition to an upfront payment, Ligand is entitled to potential milestone payments, royalties and revenue from future sales of Captisol-enabled ganaxolone.

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