Lanabecestat latest to fail in Phase III Alzheimer's program

12 June 2018

Another Alzheimer’s disease candidate looks set to be consigned to the scrap heap after failing in late-stage trials.

US pharma major Eli Lilly (NYSE: LLY) and Anglo-Swedish drugmaker AstraZeneca (LSE: AZN) announced that they were discontinuing the global Phase III studies of lanabecestat, an oral beta secretase cleaving enzyme (BACE) inhibitor that was being trialled in the degenerative neurological condition.

An independent data monitoring committee advised that both the AMARANTH trial, in early Alzheimer's disease, and the DAYBREAK-ALZ trial, in mild Alzheimer's disease dementia, were not likely to meet their primary endpoints upon completion and therefore should be stopped for futility.

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