USA-based Ionis Pharmaceuticals (Nasdaq: IONS) announced today the advancement of IONIS-FXIRx in clinical development under an existing exclusive license agreement with Germany’s Bayer (BAYN: DE).
Under this agreement, Ionis will also initiate development of IONIS-FXI-LRx, which uses Ionis' proprietary LIgand Conjugated Antisense, or LICA, technology. In conjunction with the decision to advance these programs, Ionis will receive a $75 million payment from Bayer.
"We look forward to continuing the development of IONIS-FXIRx with Bayer. IONIS-FXIRx was the first antithrombotic in development to demonstrate the potential to separate antithrombotic activity from bleeding risk. We recently completed a Phase II study in patients with end-stage renal disease on hemodialysis, in which IONIS-FXIRx demonstrated robust reductions in FXI activity and no treatment-related major bleeding," said Lynne Parshall, chief operating officer at Ionis Pharmaceuticals, adding: "We are pleased that Bayer has decided to expand our collaboration and initiate development of a LICA antisense drug targeting Factor XI. Our LICA technology enables flexible, low and infrequent doses and dose regimens, which may be preferred for a drug targeting broad indications."
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
7 day trial access
Become a subscriber
Or £77 per month
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
Copyright © The Pharma Letter 2024 | Headless Content Management with Blaze