Infection theory of Alzheimer's dealt another blow by trial hold

27 January 2022

A 30% drop in the share price of Alzheimer’s specialist Cortexyme (Nasdaq: CRTX) has followed news of an abrupt change to its clinical research priorities.

The company has been developing atuzaginstat, a novel lysine gingipain inhibitor and candidate for the treatment of Alzheimer’s, with an Investigational New Drug application under way with the US regulator.

That program is now up in the air, after the US Food and Drug Administration placed a full clinical hold on research into the candidate, for reasons which are unclear.

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