In Phase III trial, brexanolone does not benefit epilepsy patients

13 September 2017
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The Phase III STATUS trial of brexanolone has failed to meet its primary endpoint, Massachusetts, USA-based Sage Therapeutics (Nasdaq: SAGE) has revealed.

The trial was designed to study the candidate as a possible therapy for super-refractory status epilepticus (SRSE), an acute medical emergency of persistent, unremitting seizure lasting greater than five minutes.

Resolution of potentially life-threatening SRSE with brexanolone was 43.9%, compared with 42.4% for the placebo arm. All enrollees also received standard third-line anti-seizure agents.

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