Imbria secures $58 million to advance mid-stage trial for lead heart drug
US biotech Imbria Pharmaceuticals has raised $57.5 million in a series B financing round to fund a new mid-stage trial of its only pipeline drug, ninerafaxstat, for a form of heart muscle disease with limited treatment options.
The funding will support the launch of the Phase IIb FORTITUDE-HCM trial, which will evaluate ninerafaxstat in people with non-obstructive hypertrophic cardiomyopathy. Imbria expects to begin the study in the second quarter, with topline data due in late 2026.
The oral drug is being studied as a potential treatment for cardiac diseases linked to metabolic dysfunction. According to the company, it is designed to improve the heart’s energy efficiency by altering how the organ uses fuel, shifting it away from fatty acids toward glucose.
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