GSK steps in to revitalize hepatitis B candidate JNJ-3989

31 October 2023

UK pharma major GSK (LSE: GSK) and Arrowhead Pharmaceuticals (Nasdaq: ARWR) today announced an agreement for GSK to obtain an exclusive license for JNJ-3989 (formerly ARO-HBV) for treatment of chronic hepatitis B.

The investigational compound was previously in-licensed by Johnson & Johnson (NYSE: NJ) subsidiary Janssen from Arrowhead in 2018.

JNJ-3989 is an investigational hepatitis B virus-targeted small interfering ribonucleic acid (siRNA) therapeutic that GSK intends to evaluate in a sequential regimen with bepirovirsen, GSK’s investigational antisense oligonucleotide, for the treatment of adult non-cirrhotic patients with chronic hepatitis B (CHB) on nucleos(t)ide analogue (NA) therapy.

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