Gencia and Takeda team up on novel class of mitochondrial therapeutics

11 September 2015

Privately-held US drug discovery firm Gencia has entered into a partnership with Japan’s largest drugmaker Takeda Pharmaceutical (TYO: 4502) to develop a new class of small molecule drugs as potential treatments for hematological and inflammatory diseases.

Called mitochondrial agonists of the glucocorticoid receptor (MAGR), such compounds may offer the therapeutic potential of conventional glucocorticoid drugs (steroids). However, MAGR are chemically distinct and may function differently than steroids.

The initial aim of the collaboration will be joint R&D leading to two preclinical drug candidates, one each in the areas of inflammation and oncology. Takeda will explore opportunities to conduct clinical trials for drug candidates identified by the partnership.

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