Game over for pancreatic cancer candidate as Merrimack value crashes

26 June 2018

US pharma company Merrimack Pharmaceuticals (Nasdaq: MACK) lost 44% of its value on Monday.

The reason for its stock market woes was the company’s announcement of top-line results from the CARRIE study, a randomized Phase II trial evaluating the addition of MM-141 (istiratumab) to standard-of-care treatment in patients with previously untreated metastatic pancreatic cancer and high serum levels of free insulin-like growth factor-1 (IGF-1).

The study did not meet its primary or secondary efficacy endpoints in patients who received MM-141 in combination with nab-paclitaxel and gemcitabine, compared to nab-paclitaxel and gemcitabine alone. These results were consistent in all subgroups analyzed.

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