Fovista fails again in wet AMD
US eyecare specialist Ophthotech Corporation (Nasdaq: OPHT) has suffered a new setback in its attempts to develop a new treatment for wet age-related macular degeneration (AMD).
The company has announced that the pre-specified primary endpoint of mean change in visual acuity at 12 months was not achieved in its Phase III trial investigating the superiority of its drug Fovista (pegpleranib) anti-PDGF therapy in combination with Eylea (aflibercept) or Avastin (bevacizumab) anti-VEGF therapy compared to the latter two drugs as monotherapies.
Adding 1.5mg of Fovista to Regeneron (Nasdaq: REGN) and Bayer’s (BAYN: DE) Eylea, or Roche’s (ROG: SIX) Avastin, did not result in benefit as measured by the mean change in visual acuity at the 12-month time point in the OPH1004 study.
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